April 20, 2015
Case Western Reserve University School of Medicine
A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis.
Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory. The two most potent drugs – one that currently treats athlete’s foot, and the other, eczema – were capable of stimulating the regeneration of damaged brain cells and reversing paralysis when administered systemically to animal models of multiple sclerosis. The results are published online (http://dx.doi.org/10.1038/nature14335) Monday, April 20, in the scientific journal Nature.
Case Western link: http://casemed.case.edu/newscenter/news-release/newsrelease.cfm?news_id=260
Journal Nature link: http://www.nature.com/nature/journal/v522/n7555/full/nature14335.html
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