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Miconazole and Clobetasol hold promise for MS cure.

Miconazole and Clobetasol hold promise for MS cure.

Posted by Clinical on Apr 20th 2015

April 20, 2015

Case Western Reserve University School of Medicine

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis.

Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory. The two most potent drugs – one that currently treats athlete’s foot, and the other, eczema – were capable of stimulating the regeneration of damaged brain cells and reversing paralysis when administered systemically to animal models of multiple sclerosis. The results are published online (http://dx.doi.org/10.1038/nature14335) Monday, April 20, in the scientific journal Nature.

Case Western link: http://casemed.case.edu/newscenter/news-release/newsrelease.cfm?news_id=260

Journal Nature link: http://www.nature.com/nature/journal/v522/n7555/full/nature14335.html

TV news coverage Cleveland 19 News|Cleveland, OH http://www.cleveland19.com/story/29895861/case-western-closes-in-on-ms-cure?clienttype=generic